For example, suppose we wish to evaluate the integral of the function
  .  One way to do this would be to multiply the function out into
a fifteenth degree polynomial and use the basic rules, but this is not very
clever.  Instead, substitute u = 2x + 1.  Then, by taking derivatives, we
see that du = 2 dx or
 .  One way to do this would be to multiply the function out into
a fifteenth degree polynomial and use the basic rules, but this is not very
clever.  Instead, substitute u = 2x + 1.  Then, by taking derivatives, we
see that du = 2 dx or   .  So,
 .  So,
  
 
It commonly happens that du is not simply a constant times dx.  In these 
cases, we must be a little more careful.  For example, let   in the
following integral:
  in the
following integral:
 